CNR résistance aux antibiotiques
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Depuis le 01 janvier 2012, le CNR est coordonné par le Laboratoire de Bactériologie du Pr Plésiat (CHRU de Besançon).

Centre National de Référence
de la Résistance aux Antibiotiques

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Les Laboratoires

Publications de l’équipe



Antibiotic resistance and plasmid transfer capacity in biofilm formed with a CTX-M-15-producing Klebsiella pneumoniae isolate. Hennequin C, Aumeran C, Robin F, Traore O, Forestier C. J Antimicrob Chemother. 2012 Sep;67(9):2123-30.

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase. Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y. J Med Chem. 2012 Mar 8;55(5):2163-72.

Virulence factors and TEM-type β-lactamases produced by two isolates of an epidemic Klebsiella pneumoniae strain. Robin F, Hennequin C, Gniadkowski M, Beyrouthy R, Empel J, Gibold L, Bonnet R. Antimicrob Agents Chemother. 2012 Feb;56(2):1101-4.

Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme. Manageiro V, Ferreira E, Cougnoux A, Albuquerque L, Caniça M, Bonnet R. Antimicrob Agents Chemother. 2012 Feb;56(2):1042-6.

Characterization of a DHA-1-producing Klebsiella pneumoniae strain involved in an outbreak and role of the AmpR regulator in virulence. Hennequin C, Robin F, Cabrolier N, Bonnet R, Forestier C. Antimicrob Agents Chemother. 2012 Jan;56(1):288-94.

Noncovalent complexes of an inactive mutant of CTX-M-9 with the substrate piperacillin and the corresponding product. Leyssene D, Delmas J, Robin F, Cougnoux A, Gibold L, Bonnet R. Antimicrob Agents Chemother. 2011 Dec;55(12):5660-5.

Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems. Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA. Antimicrob Agents Chemother. 2011 Jul;55(7):3465-75.

In vitro efficiency of the piperacillin/tazobactam combination against inhibitor-resistant TEM- and complex mutant TEM-producing clinical strains of Escherichia coli. Robin F, Krebs M, Delmas J, Gibold L, Mirande C, Bonnet R. J Antimicrob Chemother. 2011 May;66(5):1052-6.

Characterization of the Novel CMT Enzyme TEM-154. Robin F, Delmas J, Machado E, Bouchon B, Peixe L, Bonnet R. Antimicrob Agents Chemother. 2011 Mar;55(3):1262-5.

Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids as β-lactamase inhibitors. Eidam O, Romagnoli C, Caselli E, Babaoglu K, Pohlhaus DT, Karpiak J, Bonnet R, Shoichet BK, Prati F. J Med Chem. 2010 Nov 11;53(21):7852-63.

Multidrug-resistant Klebsiella pneumoniae outbreak after endoscopic retrograde cholangiopancreatography. Aumeran C, Poincloux L, Souweine B, Robin F, Laurichesse H, Baud O, Bommelaer G, Traoré O. Endoscopy. 2010 Nov;42(11):895-9.

Structural insights into substrate recognition and product expulsion in CTX-M enzymes. Delmas J, Leyssene D, Dubois D, Birck C, Vazeille E, Robin F, Bonnet R. J Mol Biol. 2010 Jul 2;400(1):108-20.

Biochemical study of a new inhibitor-resistant beta-lactamase, SHV-84, produced by a clinical Escherichia coli strain. Manageiro V, Ferreira E, Albuquerque L, Bonnet R, Caniça M. Antimicrob Agents Chemother. 2010 May;54(5):2271-2.

CTX-M beta-lactamase production and virulence of Escherichia coli K1. Dubois D, Prasadarao NV, Mittal R, Bret L, Roujou-Gris M, Bonnet R. Emerg Infect Dis. 2009 Dec;15(12):1988-90.

Novel VIM metallo-beta-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria. Robin F, Aggoune-Khinache N, Delmas J, Naim M, Bonnet R. Antimicrob Agents Chemother. 2010 Jan;54(1):466-70.

Molecular and biochemical characterization of the natural chromosome-encoded class A beta-lactamase from Pseudomonas luteola. Doublet B, Robin F, Casin I, Fabre L, Le Fleche A, Bonnet R, Weill FX. Antimicrob Agents Chemother. 2010 Jan;54(1):45-51.

Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. Doublet B, Granier SA, Robin F, Bonnet R, Fabre L, Brisabois A, Cloeckaert A, Weill FX. Antimicrob Agents Chemother. 2009 May;53(5):1944-51.

Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. Pradel N, Delmas J, Wu LF, Santini CL, Bonnet R. Antimicrob Agents Chemother. 2009 Jan;53(1):242-8.

Biochemical characterization of SHV-55, an extended-spectrum class A beta-lactamase from Klebsiella pneumoniae. Mendonça N, Manageiro V, Bonnet R, Caniça M. Antimicrob Agents Chemother. 2008 May;52(5):1897-8.

The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. Mendonça N, Manageiro V, Robin F, Salgado MJ, Ferreira E, Caniça M, Bonnet R. Antimicrob Agents Chemother. 2008 May;52(5):1806-11.

Structure-function studies of arginine at position 276 in CTX-M beta-lactamases. Pérez-Llarena FJ, Cartelle M, Mallo S, Beceiro A, Pérez A, Villanueva R, Romero A, Bonnet R, Bou G. J Antimicrob Chemother. 2008 Apr;61(4):792-7.

Evaluation of the Vitek-2 extended-spectrum beta-lactamase test against non-duplicate strains of Enterobacteriaceae producing a broad diversity of well-characterised beta-lactamases. Robin F, Delmas J, Schweitzer C, Bonnet R. Clin Microbiol Infect. 2008 Feb;14(2):148-54.

Structure and dynamics of CTX-M enzymes reveal insights into substrate accommodation by extended-spectrum beta-lactamases. Delmas J, Chen Y, Prati F, Robin F, Shoichet BK, Bonnet R. J Mol Biol. 2008 Jan 4;375(1):192-201.

First occurrence of an IMP metallo-beta-lactamase in Aeromonas caviae: IMP-19 in an isolate from France. Neuwirth C, Siebor E, Robin F, Bonnet R. Antimicrob Agents Chemother. 2007 Dec;51(12):4486-8.

TEM-158 (CMT-9), a new member of the CMT-type extended-spectrum beta-lactamases. Robin F, Delmas J, Brebion A, Dubois D, Constantin JM, Bonnet R. Antimicrob Agents Chemother. 2007 Nov;51(11):4181-3.

The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution. Chen Y, Bonnet R, Shoichet BK. J Am Chem Soc. 2007 May 2;129(17):5378-80.

Type II topoisomerase mutations in clinical isolates of Enterobacter cloacae and other enterobacterial species harbouring the qnrA gene. Lascols C, Robert J, Cattoir V, Bébéar C, Cavallo JD, Podglajen I, Ploy MC, Bonnet R, Soussy CJ, Cambau E. Int J Antimicrob Agents. 2007 Apr;29(4):402-9.

Evolution of TEM-type enzymes: biochemical and genetic characterization of two new complex mutant TEM enzymes, TEM-151 and TEM-152, from a single patient. Robin F, Delmas J, Schweitzer C, Tournilhac O, Lesens O, Chanal C, Bonnet R. Antimicrob Agents Chemother. 2007 Apr;51(4):1304-9.

CTX-M beta-lactamase-producing Escherichia coli in French hospitals: prevalence, molecular epidemiology, and risk factors. Lavigne JP, Marchandin H, Delmas J, Moreau J, Bouziges N, Lecaillon E, Cavalie L, Jean-Pierre H, Bonnet R, Sotto A. J Clin Microbiol. 2007 Feb;45(2):620-6.

qnrA in CTX-M-producing Escherichia coli isolates from France. Lavigne JP, Marchandin H, Delmas J, Bouziges N, Lecaillon E, Cavalie L, Jean-Pierre H, Bonnet R, Sotto A. Antimicrob Agents Chemother. 2006 Dec;50(12):4224-8.

Occurrence of qnrA-positive clinical isolates in French teaching hospitals during 2002-2005. Cambau E, Lascols C, Sougakoff W, Bébéar C, Bonnet R, Cavallo JD, Gutmann L, Ploy MC, Jarlier V, Soussy CJ, Robert J. Clin Microbiol Infect. 2006 Oct;12(10):1013-20.

CMT-type beta-lactamase TEM-125, an emerging problem for extended-spectrum beta-lactamase detection. Robin F, Delmas J, Archambaud M, Schweitzer C, Chanal C, Bonnet R. Antimicrob Agents Chemother. 2006 Jul;50(7):2403-8.

Prediction of the evolution of ceftazidime resistance in extended-spectrum beta-lactamase CTX-M-9. Delmas J, Robin F, Carvalho F, Mongaret C, Bonnet R. Antimicrob Agents Chemother. 2006 Feb;50(2):731-8.

TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5). Robin F, Delmas J, Chanal C, Sirot D, Sirot J, Bonnet R. Antimicrob Agents Chemother. 2005 Nov;49(11):4443-7.

Unexpected enzyme TEM-126: role of mutation Asp179Glu. Delmas J, Robin F, Bittar F, Chanal C, Bonnet R. Antimicrob Agents Chemother. 2005 Oct;49(10):4280-7.

Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases. Chen Y, Shoichet B, Bonnet R. J Am Chem Soc. 2005 Apr 20;127(15):5423-34.

Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability. Chen Y, Delmas J, Sirot J, Shoichet B, Bonnet R. J Mol Biol. 2005 Apr 29;348(2):349-62.

Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture. Tondi D, Morandi F, Bonnet R, Costi MP, Shoichet BK. J Am Chem Soc. 2005 Apr 6;127(13):4632-9.

Frequency and diversity of Class A extended-spectrum beta-lactamases in hospitals of the Auvergne, France: a 2 year prospective study. De Champs C, Chanal C, Sirot D, Baraduc R, Romaszko JP, Bonnet R, Plaidy A, Boyer M, Carroy E, Gbadamassi MC, Laluque S, Oules O, Poupart MC, Villemain M, Sirot J. J Antimicrob Chemother. 2004 Sep;54(3):634-9.

Post-antibiotic and post-beta-lactamase inhibitor effects of ceftazidime plus sulbactam on extended-spectrum beta-lactamase-producing Gram-negative bacteria. Lavigne JP, Bonnet R, Michaux-Charachon S, Jourdan J, Caillon J, Sotto A. J Antimicrob Chemother. 2004 Apr;53(4):616-9.

Growing group of extended-spectrum beta-lactamases: the CTX-M enzymes. Bonnet R. Antimicrob Agents Chemother. 2004 Jan;48(1):1-14.

Extended-spectrum beta-lactamase TEM-24 in an Aeromonas clinical strain: acquisition from the prevalent Enterobacter aerogenes clone in France. Marchandin H, Godreuil S, Darbas H, Jean-Pierre H, Jumas-Bilak E, Chanal C, Bonnet R. Antimicrob Agents Chemother. 2003 Dec;47(12):3994-5.

Effects of Ser130Gly and Asp240Lys substitutions in extended-spectrum beta-lactamase CTX-M-9. Aumeran C, Chanal C, Labia R, Sirot D, Sirot J, Bonnet R. Antimicrob Agents Chemother. 2003 Sep;47(9):2958-61.

Effect of D240G substitution in a novel ESBL CTX-M-27. Bonnet R, Recule C, Baraduc R, Chanal C, Sirot D, De Champs C, Sirot J. J Antimicrob Chemother. 2003 Jul;52(1):29-35.

Infection with an extended-spectrum beta-lactamase-producing strain of Serratia marcescens following tongue reconstruction. Dhawan B, Bonnet R, Shukla NK, Mathur P, Das BK, Kapil A. J Clin Microbiol. 2003 May;41(5):2233-4.

Inducible AmpC beta-lactamase of a new member Enterobacteriaceae. Bonnet R, Chanal C, Ageron E, Sirot D, De Champs C, Grimont P, Sirot J. Antimicrob Agents Chemother. 2002 Oct;46(10):3316-9.

Prospective survey of beta-lactamases produced by ceftazidime- resistant Pseudomonas aeruginosa isolated in a French hospital in 2000. De Champs C, Poirel L, Bonnet R, Sirot D, Chanal C, Sirot J, Nordmann P. Antimicrob Agents Chemother. 2002 Sep;46(9):3031-4.

Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis. Bonnet R, Marchandin H, Chanal C, Sirot D, Labia R, De Champs C, Jumas-Bilak E, Sirot J. Antimicrob Agents Chemother. 2002 Jun;46(6):2004-6.

TEM derivative-producing Enterobacter aerogenes strains: dissemination of a prevalent clone. Dumarche P, De Champs C, Sirot D, Chanal C, Bonnet R, Sirot J. Antimicrob Agents Chemother. 2002 Apr;46(4):1128-31.

CTX-M-1, CTX-M-3, and CTX-M-14 beta-lactamases from Enterobacteriaceae isolated in France. Dutour C, Bonnet R, Marchandin H, Boyer M, Chanal C, Sirot D, Sirot J. Antimicrob Agents Chemother. 2002 Feb;46(2):534-7.

Novel cefotaximase (CTX-M-16) with increased catalytic efficiency due to substitution Asp-240-->Gly. Bonnet R, Dutour C, Sampaio JL, Chanal C, Sirot D, Labia R, De Champs C, Sirot J. Antimicrob Agents Chemother. 2001 Aug;45(8):2269-75.

Inhibitor-resistant TEM-33 beta-lactamase in a Shigella sonnei isolate. Sirot D, Chanal C, Bonnet R, De Champs C, Bret L. Antimicrob Agents Chemother. 2001 Jul;45(7):2179-80.

New TEM variant (TEM-92) produced by Proteus mirabilis and Providencia stuartii isolates. de Champs C, Monne C, Bonnet R, Sougakoff W, Sirot D, Chanal C, Sirot J. Antimicrob Agents Chemother. 2001 Apr;45(4):1278-80.

First isolation of a CTX-M-3-producing Enterobacter cloacae in France. Doucet-Populaire F, Ghnassia JC, Bonnet R, Sirot J. Antimicrob Agents Chemother. 2000 Nov;44(11):3239-40.

A 1998 survey of extended-spectrum beta-lactamases in Enterobacteriaceae in France. The French Study Group. de Champs C, Sirot D, Chanal C, Bonnet R, Sirot J. Antimicrob Agents Chemother. 2000 Nov;44(11):3177-9.

A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in Brazil. Bonnet R, Sampaio JL, Chanal C, Sirot D, De Champs C, Viallard JL, Labia R, Sirot J. Antimicrob Agents Chemother. 2000 Nov;44(11):3061-8.

A novel CTX-M beta-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil. Bonnet R, Sampaio JL, Labia R, De Champs C, Sirot D, Chanal C, Sirot J. Antimicrob Agents Chemother. 2000 Jul;44(7):1936-42.

Prevalence of beta-lactamases among 1,072 clinical strains of Proteus mirabilis: a 2-year survey in a French hospital. Chanal C, Bonnet R, De Champs C, Sirot D, Labia R, Sirot J. Antimicrob Agents Chemother. 2000 Jul;44(7):1930-5.

Clinical relevance of Proteus mirabilis in hospital patients: a two year survey. de Champs C, Bonnet R, Sirot D, Chanal C, Sirot J. J Antimicrob Chemother. 2000 Apr;45(4):537-9.

Diversity of TEM mutants in Proteus mirabilis. Bonnet R, De Champs C, Sirot D, Chanal C, Labia R, Sirot J. Antimicrob Agents Chemother. 1999 Nov;43(11):2671-7.

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